Description
| Details | Information |
| Brand Name | Mabtas 500 Injection |
| Active Ingredient | Rituximab |
| Strength | 500 mg |
| Available Form | Injection |
| Pack Size | 500 mg/50 mL vial |
| Medicine Type | Monoclonal Antibody |
| Manufacturer | Intas Pharmaceuticals Ltd. |
| Route of Administration | Intravenous (IV) infusion |
Mabtas 500 mg Injection is a prescription medicine that contains rituximab. It belongs to a group of medicines called monoclonal antibodies. It works by targeting certain B cells that can play a role in some cancers and autoimmune diseases.
Mabtas 500mg Injection comes in a 500 mg/50 mL vial and is given slowly into a vein (IV infusion) by a medical professional. The dose and treatment schedule of Mabtas 500mg Injection depend on the condition being treated and how the patient responds to the medicine.
It may be used for conditions such as non-Hodgkin lymphoma, chronic lymphocytic leukemia, rheumatoid arthritis, granulomatosis with polyangiitis, and microscopic polyangiitis. Since rituximab affects the immune system, regular blood tests and monitoring for infections may be needed during treatment.
What Is Mabtas 500 mg Injection?
Mabtas 500 Injection contains rituximab 500 mg, which targets certain B cells in the body. It belongs to a group of medicines called monoclonal antibodies. Mabtas 500 is used to treat certain blood cancers and autoimmune conditions.
Mabtas 500 mg is available as a 500 mg/50 mL injection and is given slowly into a vein through an intravenous (IV) infusion. It should only be administered by a trained medical professional.
Before starting treatment, the medical team may review your health history, current medicines, infection history, and vaccination status. The dose and treatment schedule depend on the condition being treated and your individual health needs.
How Does Mabtas 500 Injection Work?
Rituximab 500mg works by recognizing a protein called CD20 found on the surface of certain B cells. It attaches to these cells and helps the immune system remove them from the body.
B cells are a type of immune cell that helps the body fight infections. However, certain cancers can cause abnormal B cells to grow, while in some autoimmune diseases, B cells can contribute to an overactive immune response.
By reducing these targeted B cells, Mabtas 500 injection helps control the disease and may reduce abnormal immune activity. The time needed to see improvement can vary depending on the condition and individual response to treatment.
Uses Of Mabtas 500 Injection
Mabtas 500 mg Injection may be used in the treatment of several conditions, including:
- Non-Hodgkin lymphoma (NHL): It helps target certain abnormal B cells involved in this type of blood cancer.
- Chronic lymphocytic leukemia (CLL): It may be used to treat certain types of CLL as part of a treatment plan.
- Rheumatoid arthritis: It helps reduce the activity of B cells that contribute to the abnormal immune response.
- Granulomatosis with polyangiitis (GPA): It helps control the abnormal immune response that causes inflammation in the blood vessels.
- Microscopic polyangiitis (MPA): It may help reduce the abnormal immune activity responsible for inflammation of small blood vessels.
The dose and treatment duration depend on the condition being treated and the patient’s response. Mabtas 500 Injection should be given only under medical supervision and should not be self-administered.
How Is Mabtas 500 Injection Given?
Mabtas 500 Injection is given slowly into a vein through an intravenous (IV) infusion. It should only be given by a trained medical professional and should not be used by yourself.
Before starting the infusion, medicines may be given to help reduce the chance of reactions. During treatment, the medical team will monitor you for symptoms such as fever, chills, breathing problems, or changes in blood pressure.
The first dose may need closer monitoring because infusion reactions can be more common during the first treatment. The infusion speed may be changed depending on how you respond.
The dose of Mabtas 500 mg and the time between doses depend on the condition being treated. Do not change or repeat the dose unless advised by your treating medical professional.
Strengths and Substitutes
Side Effects Of Mabtas 500 Injection
Mabtas 500 Injection may cause some side effects. These effects can vary from person to person and may depend on the condition being treated and other medicines used during treatment.
Common side effects may include:
- Headache
- Fever
- Chills
- Weakness
- Nausea
- Infections
- Infusion-related reactions
- Changes in blood cell counts
- Abdominal pain
- Back pain
Infusion-related reactions can happen during or soon after the injection. Symptoms may include fever, chills, rash, breathing difficulty, or changes in blood pressure. These reactions are more common during the first infusion, so patients are closely monitored during treatment.
Mabtas 500 Injection can also affect the immune system and reduce certain blood cells, which may increase the risk of infections. Hepatitis B infection can also become active again in some patients.
Precautions & Warnings Of Mabtas 500 Injection
Before receiving Mabtas 500 mg, tell the treating medical professional about your complete medical history and all medicines you use.
Important precautions include:
- Infections: Inform the medical team about any current or recent infection. Rituximab can affect immune function and may increase infection risk.
- Hepatitis B: Screening and appropriate monitoring for hepatitis B may be required before and during treatment because rituximab treatment can be associated with hepatitis B reactivation.
- Heart problems: Tell the medical team if you have a history of heart disease, abnormal heart rhythm, or other cardiovascular problems.
- Lung problems: Existing breathing or lung conditions should be discussed before treatment, particularly because infusion reactions can sometimes affect breathing.
- Vaccinations: Tell the medical team about recent or planned vaccinations. Vaccine responses may be affected during B-cell-depleting treatment, and vaccination timing should be planned appropriately.
- Pregnancy and breastfeeding: If you are pregnant, planning pregnancy, or breastfeeding, discuss this with the treating medical professional before receiving rituximab. Appropriate contraception and pregnancy-planning advice may be required depending on the treatment situation.
- Surgery: Inform the medical team if you are scheduled for surgery or have recently undergone a procedure.
Regular monitoring may include blood tests and other assessments according to the condition being treated.
Mabtas 500 Injection Drug Interactions
Mabtas 500 Injection may interact with certain medicines and treatments. Inform your healthcare professional about all medicines, supplements, and other treatments you are currently using.
Special care may be needed when Mabtas 500 is used with:
- Medicines that lower the immune system
- Cancer medicines
- Other biological medicines
- Medicines that can affect blood-cell counts
- Vaccines
Some medicine combinations may increase the risk of infections or other side effects. Do not start, stop, or change any medicine without proper medical advice. Vaccinations may also need special planning during treatment because rituximab 500mg can affect the body’s immune response to some vaccines.
Mabtas 500 Injection Storage
Mabtas 500 Injection should be stored under refrigerated conditions, generally between 2°C and 8°C (36°F and 46°F). The vial should be kept in its original carton to protect it from light. It should not be frozen or shaken. Because rituximab 500mg/50ml is an injectable biological medicine, proper storage and handling are important for maintaining product quality.
